Trifluoroacetic acid → 4-Amino-6-chloropyrimidine-2-thiol

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9]CC2C=CC(OC)=CC=2)[N:3]=1.FC(F)(F)C(O)=O>>[CH:7]1[C:2]([NH2:1])=[N:3][C:4](=[S:9])[NH:5][C:6]=1[Cl:8]

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 470536HCID 470536, 화합물

생성물 1

HCID 105153224-Amino-6-chloropyrimidine-2-thiol

실험 절차

4-amino-6-chloro-2-(4-methoxyphenylmethylthio)-pyrimidine (11.0 g, 39.15 mmol; Cpd #93) and trifluoroacetic acid (84 ml) are heated to reflux for 20 hours, then the excess solvent is removed in vacuo. The sample is triturated with chloroform then stirred with ether and filtered. The solid is washed with ether then air dried, mp >320° C.

후처리

temperatureto reflux for 20 hours
customthe excess solvent is removed in vacuo
customThe sample is triturated with chloroform
filtrationfiltered
washThe solid is washed with ether
customair dried

출처 및 근거

ORD 기록: ord-216679d7b3aa436191bed64e336747e4
출처 데이터셋: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06043248

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