2-Formylisonicotinonitrile → HCID 18799766, 화합물

반응식

C(C1C=CN=C(C=O)C=1)#N.[OH:11][CH2:12][C:13]1[CH:18]=[C:17]([CH2:19][N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH:16]=[CH:15][N:14]=1>>[N:20]1([CH2:19][C:17]2[CH:16]=[CH:15][N:14]=[C:13]([CH:12]=[O:11])[CH:18]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

참가 물질

반응물 2

HCID 147614682-Formylisonicotinonitrile

HCID 18799862HCID 18799862, 화합물

생성물 1

HCID 18799766HCID 18799766, 화합물수율 45.4%

실험 절차

In a manner similar to that reported for the preparation of 4-cyano-2-pyridine-carboxaldehyde, 2-hydroxymethyl-4-(4-morpholinyl)methylpyridine (2.29 g, 11.01 mmol) gave 1.03 g (45%) of 4-(4-morpholinyl)methyl-2-pyridine carboxaldehyde.

출처 및 근거

ORD 기록: ord-69f23d2112764ab4ad27e8122ac28f19
출처 데이터셋: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06043248

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