Ethyl isocyanate → HCID 14601661, 화합물

HRID 1638289노트

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HRID 1638289 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)=[O:13])[C:6]=2[CH:21]=1.[CH2:22]([N:24]=[C:25]=[O:26])[CH3:23]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][CH:17]([O:20][C:25](=[O:26])[NH:24][CH2:22][CH3:23])[CH2:18][CH2:19]3)=[O:13])[C:6]=2[CH:21]=1

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 3082453Hpr 611

생성물 1

HCID 14601661HCID 14601661, 화합물수율 77%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
50 °C

실험 절차

5-Chloro-3-(4-hydroxypiperidinocarbonylmethyl)benzothiazolin-2-one (3.2 g) was dissolved in dry pyridine (15 ml) and the solution was cooled. After ethyl isocyanate (0.9 g) was dropwise added to the solution, the resultant was stirred for 10 hours at 50° C. Pyridine was evaporated off under vacuum from the reaction mixture and the residue was recrystallized from ethanol to yield the title compound as colorless crystals (3.0 g). mp 210°-211° C.

후처리

  1. temperaturethe solution was cooled
  2. customPyridine was evaporated off under vacuum from the reaction mixture
  3. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-e9a7cdace81f4524b93ffcfcc41921c6
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04879301

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