Ethyl bromopyruvate → HCID 19842281, 화합물
반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[S:8])[NH2:7].Br[CH2:10][C:11](=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13]>C(O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:8][CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:7]=1참가 물질
4
실험 절차
To a solution of 2-furan-thiocarboxamide (1.63 g) dissolved in dry ethanol (65 ml) with heating was added ethyl bromopyruvate (1.97 ml) and the mixture was refluxed for 30 minutes. Then the solvent was removed from the reaction mixture, and the residue was treated with water, neutralized with 4% aqueous sodium carbonate and extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous NaCl, dried (anhydrous Na2SO4) and concentrated to give yellowish crystals of ethyl 2-(2-furyl)-4-thiazolecarboxylate (3.12 g).
후처리
- temperaturewith heating
- temperaturethe mixture was refluxed for 30 minutes
- customThen the solvent was removed from the reaction mixture
- additionthe residue was treated with water
- extractionextracted three times with ethyl acetate
- washThe organic layer was washed with saturated aqueous NaCl
- dry with materialdried (anhydrous Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-0192acb3e34d4d51889bafa6a63cac9f
- 출처 데이터셋
- uspto-grants-1989_11
- 특허 번호
- US04879295
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