Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Malononitrile → Dihydro-2H-pyran-4,4(3H)-dicarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Malononitrile | HCID 8010 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,1'-Oxybis(2,2-dichloroethane) | HCID 62383 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Dihydro-2H-pyran-4,4(3H)-dicarbonitrile | HCID 14537194 | — |
반응 단계
According to Flowchart B dichloroethyl ether (7) and malononitrile (8) are reacted with potassium carbonate in acetonitrile at reflux, giving tetrahydro-4H-pyran-4,4-dicarbonitrile (9) which is then reacted with 1N borane in tetrahydrofuran followed by treatment with hydrochloric acid, giving tetrahydro-4H-pyran-4,4-dimethanamine dihydrochloride (10) which is then reacted with sodium acetate and potassium tetrachloroplatinate in water, giving the product (11). ##STR7## In Flowchart C, compound 13 is derived by treating 12 with chlorine gas in dilute hydrochloric acid. ##STR8## In Flowchart D, compound 15 is derived by treating 14 with hydrogen peroxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04880790 |
| 출처 데이터셋 | uspto-grants-1989_11 |
| ORD ID | ord-ffde2efc1cad455591c1cdd698b05fa3 |
| 출처 메모 | uspto-grants-1989_11 |