Triethylamine → 2-(Chloromethyl)-1,3,4-trifluorobenzene

HRID 1638679

반응식

HRID 1638679 반응식
[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([F:11])[C:3]=1[CH2:4]O.S(Cl)([Cl:14])=O.C(N(CC)CC)C>ClCCl>[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([F:11])[C:3]=1[CH2:4][Cl:14]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 1455002,3,6-Trifluorobenzyl alcohol

생성물 1

HCID 156318382-(Chloromethyl)-1,3,4-trifluorobenzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 2,3,6-trifluorobenzyl alcohol (41 g) in dichloromethane (100 ml) is added dropwise a solution of thionyl chloride (50 ml) in dichloromethane (80 ml) under ice cooling with stirring, and the mixture is stirred at room temperature overnight. To the mixture is added triethylamine (10 ml), and the solvent is distilled off under reduced pressure to give 2,3,6-trifluorobenzyl chloride (28.6 g), as colorless oil, b.p. 63;L ° C. (13 mmHg).

후처리

  1. stirringthe mixture is stirred at room temperature overnight
  2. distillationthe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-51b1acbec42647b0b69e98c434852989
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04880806

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