Sodium Cyanide → 2,3,6-Trifluorophenylacetonitrile
반응식
[C-:1]#[N:2].[Na+].[F:4][C:5]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:6]=1[CH2:7]Cl>O.[Cl-].C1([N+](CC)(CC)CC)C=CC=CC=1>[F:4][C:5]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:6]=1[CH2:7][C:1]#[N:2]참가 물질
5
실험 절차
To a solution of sodium cyanide (1.94 g) in water (4 ml) is added phenyltriethylammonium chloride (0.09 g), and thereto is added with stirring 2,3,6-trifluorobenzyl chloride (5.0 g), and the mixture is stirred at 90° to 100° C. for 40 minutes. The reaction mixture is poured into water (20 ml) and is extracted with diethyl ether. The extract is dried over potassium carbonate and the solvent is distilled off to give 2-(2,3,6-trifluorophenyl)acetonitrile (3.1 g), b.p. 80°-85° C. (5 mmHg).
후처리
- extractionis extracted with diethyl ether
- dry with materialThe extract is dried over potassium carbonate
- distillationthe solvent is distilled off
출처 및 근거
- ORD 기록
- ord-c8cdabf856714ec99083d7b88f92ab5c
- 출처 데이터셋
- uspto-grants-1989_11
- 특허 번호
- US04880806
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