(3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester → 1-[(3R,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]ethanone

HRID 16390노트

반응식

HRID 16390 반응식
C(OC([N:11]1[C@H:16]([C:17]2[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[CH:18]=2)[CH2:15][O:14][CH2:13][C@@H:12]1[C:26](=[O:28])[CH3:27])=O)C1C=CC=CC=1>C(O)C.[C].[Pd]>[F:23][C:21]1[CH:22]=[C:17]([C@H:16]2[NH:11][C@@H:12]([C:26](=[O:28])[CH3:27])[CH2:13][O:14][CH2:15]2)[CH:18]=[C:19]([F:25])[C:20]=1[F:24]

참가 물질

4

반응물 1

HCID 67372176(3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester

생성물 1

HCID 673707471-[(3R,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]ethanone수율 100.3%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A suspension of (3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester (800 mg) and 10% palladium-carbon (79.2 mg, 50% water content) in ethanol (15 mL) was stirred under a hydrogen atmosphere for 15 minutes. The catalyst was filtered off over Celite. The obtained filtrate was concentrated, to thereby obtain the titled compound (529 mg). The physical properties of the compound were as follows.

후처리

  1. filtrationThe catalyst was filtered off over Celite
  2. concentrationThe obtained filtrate was concentrated

출처 및 근거

ORD 기록
ord-c5ddc4150cdf4cbc8669a1f35b2efa29
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737141B2

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