Pyridine → 7-Chloromethyl-2-phenylbenzofuran

HRID 1639025노트

반응식

HRID 1639025 반응식
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[C:15]2[O:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.N1C=CC=CC=1>C(Cl)Cl>[Cl:3][CH2:6][C:7]1[C:15]2[O:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][C:11]=2[CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 145149497-Hydroxymethyl-2-phenylbenzofuran

생성물 1

HCID 145149507-Chloromethyl-2-phenylbenzofuran수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (0.65 ml) is added to a mixture of 7-hydroxymethyl-2-phenylbenzofuran (1.0 g), pyridine (0.38 ml) and methylene chloride (8 ml) under ice-cooling, and the mixture is stirred at room temperature for 30 minutes. The mixture is concentrated under reduced pressure to remove solvent, and the residue is dissolved in ethyl acetate. The solution is washed with water, dried and concentrated under reduced pressure to remove solvent. The residue is recrystallized from n-hexane, whereby 7-chloromethyl-2-phenylbenzofuran (0.9 g) is obtained. Yield: 83%.

후처리

  1. temperaturecooling
  2. concentrationThe mixture is concentrated under reduced pressure
  3. customto remove solvent
  4. dissolutionthe residue is dissolved in ethyl acetate
  5. washThe solution is washed with water
  6. customdried
  7. concentrationconcentrated under reduced pressure
  8. customto remove solvent
  9. customThe residue is recrystallized from n-hexane

출처 및 근거

ORD 기록
ord-00b493add8be4a1ea89eca47e3cfe90e
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04882340

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