Styrene Oxide → 2-Allylamino-1-phenyl-ethanol

HRID 1639157노트

반응식

HRID 1639157 반응식
[CH2:1]1[O:9][CH:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([NH2:13])[CH:11]=[CH2:12]>>[CH2:10]([NH:13][CH2:1][CH:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[OH:9])[CH:11]=[CH2:12]

참가 물질

3

반응물 2

HCID 7276Styrene OxideHCID 7853Allylamine

생성물 1

HCID 2925542-Allylamino-1-phenyl-ethanol

실험 절차

A mixture of styrene oxide (24 mL, 0.2 moles) and allylamine (60.8 mL, 0.8 moles) was heated to reflux under nitrogen atmosphere, for 24 hours. Upon cooling, product crystallized and was triturated with hexane. Recrystallization from hexane afforded the title compound essentially uncontaminated by the other possible regioisomer. Ms m+/z=177; H1NMR (CDCl3): δ 7.3 (br.s, 5H), 5.6-6.1 (m, 1H), 4.9-5.4 (m, 2H), 4.75 (m, 1H), 3.2 (br.d, 2H), 2.9 (br.s, 2H), 2.7 (m, 2H).

후처리

  1. temperaturewas heated
  2. temperatureto reflux under nitrogen atmosphere, for 24 hours
  3. temperatureUpon cooling
  4. customproduct crystallized
  5. customwas triturated with hexane
  6. customRecrystallization from hexane

출처 및 근거

ORD 기록
ord-cc843f7929f04dc0a82af1ef5073e075
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04882429

반응 노트

불러오는 중…