Iodoacetic Acid → Diethyl 2-[(iodoacetyl)amino]malonate

반응식

[NH2:1][CH:2]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[I:13][CH2:14][C:15](O)=[O:16]>>[I:13][CH2:14][C:15]([NH:1][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:16]

참가 물질

반응물 2

HCID 5240Iodoacetic Acid

HCID 81272Propanedioic acid, 2-amino-, 1,3-diethyl ester

생성물 1

HCID 15096465Diethyl 2-[(iodoacetyl)amino]malonate

실험 절차

Diethyl 2-aminomalonate and iodoacetic acid are treated in the same manner as described in Reference Example 1 to give diethyl 2-[(iodoacetyl)amino]malonate, m.p. 96°-98° C.

출처 및 근거

ORD 기록: ord-3014e318e731428a9a99bd718c921f77
출처 데이터셋: uspto-grants-1989_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04882447

반응 노트

불러오는 중…