Acrylamide → 8-chloro-1,4,5,6-tetrahydrobenzo[f]quinolin-3(2H)-one
반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([N:12]1[CH2:16][CH2:15][CH2:14]C1)[CH2:6][CH2:5]2.C(N)(=[O:20])C=C>C(O)C>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]3[CH2:14][CH2:15][C:16](=[O:20])[NH:12][C:7]=3[CH2:6][CH2:5][C:4]=2[CH:3]=1참가 물질
4
실험 절차
701 g (3 mol) of 1-(6-chloro-3,4-dihydro-2-naphthyl)-pyrrolidine and 640 g (19 mol) of acrylamide in 7 ml of ethanol are boiled under reflux for 3 days with the addition of 70 g of Amberlite IR200. The separated solid is removed by filtration, extractively crystallized with dioxane and there is obtained 8-chloro-1,4,5,6-tetrahydrobenzo[f]-quinolin-3(2H)-one with melting point 228°-230° C.
후처리
- temperatureunder reflux for 3 days with the addition of 70 g of Amberlite IR200
- customThe separated solid is removed by filtration
- customextractively crystallized with dioxane
출처 및 근거
- ORD 기록
- ord-cc85e2db7142473394fe502977c273ba
- 출처 데이터셋
- uspto-grants-1989_11
- 특허 번호
- US04883815
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