Acetyl chloride → N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

HRID 1639468노트

반응식

HRID 1639468 반응식
[Br-:1].[CH2:2]([N+:14]([CH3:19])([CH3:18])[CH2:15][CH2:16][OH:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[Na+].[Na+].[C:26](Cl)(=[O:28])[CH3:27]>CC(C)=O>[Br-:1].[CH2:2]([N+:14]([CH3:19])([CH3:18])[CH2:15][CH2:16][O:17][C:26](=[O:28])[CH3:27])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 10340Sodium CarbonateHCID 814861-Dodecanaminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1)

생성물 1

HCID 13914766N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

In a reaction vessel was placed 13.14 grams of dodecyl dimethyl 2-hydroxyethyl ammonium bromide, 21.22 grams of acetone solvent and 4.72 grams of sodium carbonate. While stirring under nitrogen, 3.27 grams of acetyl chloride was added dropwise. Gas evolution occurred. The mixture was then refluxed (ca. 60° C.) for 6 hours. The solvent was removed under vacuum. The residue was extracted with isopropanol to dissolve the quat and the solution was filtered hot to remove sodium chloride and sodium carbonate. The filtrate was evaporated under vacuum leaving as the product dodecyl dimethyl acetyloxyethyl ammonium bromide.

후처리

  1. customIn a reaction vessel was placed
  2. customThe solvent was removed under vacuum
  3. extractionThe residue was extracted with isopropanol
  4. dissolutionto dissolve the quat
  5. filtrationthe solution was filtered hot
  6. customto remove sodium chloride and sodium carbonate
  7. customThe filtrate was evaporated under vacuum

출처 및 근거

ORD 기록
ord-a15305a36dcb4d6c9de5724f6bec8a22
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04883917

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