Nitric Acid → 7-nitro-5H-pyrrolo[2,3-b]pyrazine

HRID 1639578

반응식

HRID 1639578 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[NH:7][CH:8]=[CH:9][C:2]=12.[N+:10]([O-])([OH:12])=[O:11].C(=O)(O)[O-].[Na+]>O>[N+:10]([C:9]1[C:2]2[C:3](=[N:4][CH:5]=[CH:6][N:1]=2)[NH:7][CH:8]=1)([O-:12])=[O:11]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 516892Sodium BicarbonateHCID 53708035H-Pyrrolo[2,3-b]pyrazine

생성물 1

HCID 122071927-nitro-5H-pyrrolo[2,3-b]pyrazine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared by adding 5H-pyrrolo[2,3-b]pyrazine (3) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 7-nitro-5H-pyrrolo[2,3-b]pyrazine 5.

후처리

  1. custom7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared
  2. additionis carefully added
  3. filtrationThe solids are collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-2f08133920194a08827817773bbfdaf3
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110576B2

연결된 노트

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