Acetohydroxamic Acid → 4-Methoxy-1,2-benzoxazol-3-amine

HRID 16396노트

반응식

HRID 16396 반응식
[C:1]([NH:4][OH:5])(=O)[CH3:2].CC(C)([O-])C.[K+].F[C:13]1[CH:20]=[CH:19]C=[C:17]([O:21][CH3:22])[C:14]=1C#N.[Cl-].[Na+].C[N:26](C)C=O>>[CH3:22][O:21][C:17]1[C:2]2[C:1]([NH2:26])=[N:4][O:5][C:19]=2[CH:20]=[CH:13][CH:14]=1

참가 물질

6

반응물 5

HCID 1990Acetohydroxamic AcidHCID 5234Sodium ChlorideHCID 6228DimethylformamideHCID 5231012-Fluoro-6-methoxybenzonitrileHCID 23665647Potassium tert-butoxide

생성물 1

HCID 27797514-Methoxy-1,2-benzoxazol-3-amine

반응 조건

온도
60 °C

실험 절차

709.5 mg (9.45 mmol) of acetohydroxamic acid are initially charged in 8 ml of anhydrous dimethylformamide, and 1.06 g (9.45 mmol) of potassium tert-butoxide are added at room temperature. After 40 minutes of stirring, 1 g (6.62 mmol) of 2-fluoro-6-methoxybenzonitrile is added. The mixture is heated at 60° C. for 16 hours. 20 ml of saturated sodium chloride solution are then added to the reaction mixture. The precipitated crystals are filtered off with suction and washed with water.

후처리

  1. filtrationThe precipitated crystals are filtered off with suction
  2. washwashed with water

출처 및 근거

ORD 기록
ord-acb4e7ee3dec4c4ea677ed50342c344e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

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