Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1639765생성일: 2026년 10월 26일
3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol → (2Z)-3-(2-methyl-2H-indazol-4-yl)prop-2-en-1-ol
https://huagongshe.com/reaction/1639765
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol | HCID 59334645 | — |
| 촉매 | Palladium on calcium carbonate | HCID 17803853 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (2Z)-3-(2-methyl-2H-indazol-4-yl)prop-2-en-1-ol | HCID 59334468 | 82.2% |
반응 단계
Under hydrogen gas atmosphere, a mixture of 3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol (50.0 mg, 0.269 mmol) and 5% palladium-calcium carbonate (lead poisoned, Lindlar catalyst, 5 mg) in methanol (3 mL) was stirred at −10° C. for 90 min, and filtered. The solvent was evaporated under reduced pressure. The residue was washed with diisopropyl ether to give the title compound (41.6 mg, yield 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08110585B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_02 |
|---|
| ORD ID | ord-021d794e88834ceeb678342fd71f35ed |
|---|
| 출처 메모 | uspto-grants-2012_02 |
|---|
