Hydrochloride methanol → 1-[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639786노트

반응식

HRID 1639786 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@@H:12]1[CH2:14][C@H:13]1[CH2:15][NH:16]C(=O)OC(C)(C)C.[ClH:24].CO>CO>[ClH:24].[ClH:24].[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@@H:12]1[CH2:14][C@H:13]1[CH2:15][NH2:16]

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 59334581tert-butyl {[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl)carbamate

생성물 1

HCID 667206571-[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride수율 79%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl {[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}carbamate (343 mg, 1.07 mmol) in methanol (1 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 3 mL) solution, and the mixture was stirred at room temperature for 14 hr. The solvent was concentrated under reduced pressure and the obtained crystals were washed with ethyl acetate to give the title compound (246 mg, yield 79%).

후처리

  1. concentrationThe solvent was concentrated under reduced pressure
  2. washthe obtained crystals were washed with ethyl acetate

출처 및 근거

ORD 기록
ord-128c43b9f008436c96c6c9b17e422daa
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110585B2

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