Hydrochloride methanol → 1-[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639817노트

반응식

HRID 1639817 반응식
[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@@H:10]3[CH2:12][C@H:11]3[CH2:13][NH:14]C(=O)OC(C)(C)C)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[ClH:23].CO>CO>[ClH:23].[ClH:23].[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@@H:10]3[CH2:12][C@H:11]3[CH2:13][NH2:14])=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 59334467tert-butyl {[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate

생성물 1

HCID 667206351-[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochloride수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl {[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate (1.71 g, 5.67 mmol) in methanol (6 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 18 mL) solution and the mixture was stirred at room temperature for 15 hr. The solvent was concentrated under reduced pressure to give the title compound (1.61 g, yield 100%).

후처리

  1. concentrationThe solvent was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6199c94954ab46fba2bdc4e35a134e0f
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110585B2

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