Potassium Carbonate → 2-(2-Chloro-phenyl)pyridine

HRID 1639939

반응식

HRID 1639939 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.Br[C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd].O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:13]1[CH:12]=[CH:17][CH:16]=[CH:15][N:14]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 122863-BromopyridineHCID 27343222-Chlorophenylboronic acid

생성물 1

HCID 111481852-(2-Chloro-phenyl)pyridine수율 50%

시약·촉매·용매 2

HCID 11979704Tetrakis(triphenylphosphine)palladium촉매HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

This Example was carried out in the same manner as Example 1, except that 5.0 g (0.032 mol) of 2-chloro-phenyl boronic acid, 10.0 g (0.064 mol) of 3-bromopyridine, 150□ of tetrahydrofuran and 2M potassium carbonate solution (20□) were added and then 0.37 g (3 mol %) of palladium tetrakistriphenylphosphine [(pd(PPh3)4] was used as a catalyst. Finally, after the resulting solution was heated to reflux at 80° C. for 24 hours, the 2-(2-chloro-phenyl)pyridine was isolated. The yield was 50%.

후처리

  1. additionwere added
  2. temperatureFinally, after the resulting solution was heated

출처 및 근거

ORD 기록
ord-ced71b5bffbd47b3877cc858e5ce65b0
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110642B2

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