참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | tert-Butylphosphine | HCID 123165 | — |
| 반응물 | 4-Vinylphenylboronic acid | HCID 2734393 | — |
| 반응물 | 3-(4-Chlorophenyl)pyridine | HCID 13160546 | — |
| 반응물 | HCID 178506427 | HCID 178506427 | — |
| 촉매 | Tris(dibenzylideneacetone) palladium | HCID 44556509 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-(4'-Vinyl-biphenyl-4-yl)pyridine | HCID 66722382 | 47% |
반응 단계
This Example was carried out in the same manner as Example 10, except that 23.42 g (0.158 mol) of 4-vinyl-phenyl boronic acid, 20.0 g (0.1055 mol) of 3-(4-chloro-phenyl)pyridine, 500□ of 1,4-dioxane, 27.54 g (0.474 mol, 3.3 equivalent) of fluoro-potassium, 1.69 g (0.0084 mol, 5.3 mol %) of t-butylphosphine [P( t-Bu)3)], and 2.6 g (0.0028 mol, 1.8 mol %) of palladium tris(dibenzylidene acetone) [Pd2(dba)3] were used. Finally, after the resulting solution was heated to reflux at 80° C. for 24 hours, the 3-(4′-vinyl-biphenyl-4-yl)pyridine was isolated. The yield was 47%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08110642B2 |
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| 출처 데이터셋 | uspto-grants-2012_02 |
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| ORD ID | ord-4a13d73d0b49414bad383b8e540dcb40 |
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| 출처 메모 | uspto-grants-2012_02 |
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