HCID 24757386, 화합물 → HCID 24757470, 화합물
반응식
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C:12]3[CH:17]=[CH:16][C:15]([CH:18]([CH3:26])[C:19]([O:21]C(C)(C)C)=[O:20])=[CH:14][CH:13]=3)[C:8]2=[O:11])=[CH:4][CH:3]=1>C(O)=O>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C:12]3[CH:13]=[CH:14][C:15]([CH:18]([CH3:26])[C:19]([OH:21])=[O:20])=[CH:16][CH:17]=3)[C:8]2=[O:11])=[CH:4][CH:3]=1참가 물질
3
실험 절차
A mixture of tert-butyl 2-(4-(6-chloro-1-oxoisoindolin-2-yl)phenyl)propanoate (0.157 g, 0.422 mmol) and formic acid (15.7 mL) was stirred overnight at room temperature. The mixture was then concentrated under reduced pressure, suspended in hexanes (5 mL), sonicated, and the solids collected by filtration to afford 2-(4-(6-chloro-1-oxoisoindolin-2-yl)phenyl)propanoic acid (0.118 g, 89%) as a white solid: mp 235-248° C. (dec); 1H NMR (500 MHz, DMSO-d6) δ 12.35 (br s, 1H), 7.83 (d, J=8.5 Hz, 2H), 8.44 (s, 1H), 7.78 (m, 2H), 7.51 (m, 2H), 5.02 (s, 2H), 3.69 (q, J=7.0 Hz, 1H), 1.38 (d, J=7.0 Hz, 3H); ESI MS m/z 348 [M+H+CH3OH]+.
후처리
- concentrationThe mixture was then concentrated under reduced pressure