Aniline → Aniline, N-(2,2,2-trifluoroethyl)-

HRID 1640234

반응식

HRID 1640234 반응식
FC(F)(F)S(O[CH2:7][C:8]([F:11])([F:10])[F:9])(=O)=O.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[F:9][C:8]([F:11])([F:10])[CH2:7][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

생성물 1

HCID 9596Aniline, N-(2,2,2-trifluoroethyl)-

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

2.5 g (10.7 mmol) 2,2,2-trifluoroethyl trifluoromethanesulphonate were added to 2.0 g (21.5 mmol) aniline in 50 mL xylene and the mixture was refluxed for 2 days. After cooling, the mixture was filtered, washed with DIPE and the filtrate was evaporated down i.vac. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.

후처리

  1. temperaturethe mixture was refluxed for 2 days
  2. temperatureAfter cooling
  3. filtrationthe mixture was filtered
  4. washwashed with DIPE
  5. customthe filtrate was evaporated down i.vac
  6. customThe residue was purified by flash chromatography
  7. customevaporated down i.vac

출처 및 근거

ORD 기록
ord-1e0a5ea719cf40c5a311b798f7ce4fb7
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110575B2

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