Phenethylamine → 2,2,2-Trifluoro-N-(2-phenylethyl)ethan-1-amine
반응식
[F:1][C:2]([F:13])([F:12])[CH2:3]OS(C(F)(F)F)(=O)=O.[CH2:14]([NH2:22])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C(C)=CC=CC=1>[CH2:14]([NH:22][CH2:3][C:2]([F:13])([F:12])[F:1])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1참가 물질
4
실험 절차
1.9 g (8.3 mmol) 2,2,2-trifluoroethyltrifluoromethanesulphonate were added to 2.0 g (16.5 mmol) phenethylamine in 50 mL xylene and the reaction mixture was refluxed overnight. After cooling the precipitate formed was suction filtered, washed with DIPE and the filtrate washed evaporated down i.vac. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.
후처리
- temperaturethe reaction mixture was refluxed overnight
- temperatureAfter cooling the precipitate
- customformed
- filtrationfiltered
- washwashed with DIPE
- washthe filtrate washed
- customevaporated down i.vac
- customThe residue was purified by flash chromatography
- customevaporated down i.vac
출처 및 근거
- ORD 기록
- ord-3b6f770e15b4411da73f674d6141b332
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08110575B2
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