Hydrochloric Acid → 5-(6-(2-propylindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

참여 물질

반응 단계

12.5 μL (50 μmol) 4M aqueous hydrochloric acid were added to 103 mg (0.40 mmol) (6-chloro-pyrimidin-4-yl)-(2-propyl-2,3-dihydro-indol-1-yl)-methanone and 108 mg (0.36 mmol) 5-amino-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one in 2 mL 2-pentanol. The reaction mixture was refluxed for 2 h. The reaction mixture was evaporated down using the rotary evaporator and the residue was taken up in DMF. The purification was carried out by preparative HPLC. The product fractions were combined and lyophilised.

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