Piperidine → N-(5-methyl-1H-pyrazol-3-yl)-6-(piperidin-1-yl)-2-styrylpyrimidin-4-amine

HRID 1640431노트

반응식

HRID 1640431 반응식
[C:1](#[N:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH2:17])[CH:13]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH:17][C:3]2[CH:2]=[C:1]([N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[N:10]=[C:1]([CH:2]=[CH:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:10]=2)[CH:13]=1

참가 물질

4

반응물 3

HCID 8082PiperidineHCID 746673-Phenylprop-2-enenitrileHCID 931461H-Pyrazol-3-amine, 5-methyl-

생성물 1

HCID 66738754N-(5-methyl-1H-pyrazol-3-yl)-6-(piperidin-1-yl)-2-styrylpyrimidin-4-amine

실험 절차

Example 67 was synthesized via Scheme 6 according to the general scheme provided above with the appropriate starting materials cinnamonitrile, 5-methyl-1H-pyrazole-3-amine, and piperidine. Structure of the target was confirmed by 1H-NMR. The 1H-NMR is attached.

후처리

  1. customExample 67 was synthesized via Scheme 6 according to the general scheme
  2. customprovided above with the

출처 및 근거

ORD 기록
ord-00dbd1e402c94f5c9babd78eacd99ff0
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114870B2

반응 노트

불러오는 중…