Imidazole → Tert-butyl-hex-5-enyloxy-dimethyl-silane
반응식
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[CH3:8][C:9]([Si:12](Cl)([CH3:14])[CH3:13])([CH3:11])[CH3:10].N1C=CN=C1.O>C1COCC1>[C:9]([Si:12]([O:7][CH2:1][CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6])([CH3:14])[CH3:13])([CH3:11])([CH3:10])[CH3:8]참가 물질
6
실험 절차
To a solution of 5-hexen-1-ol (5 g, 50 mmol) in THF (80 mL) were sequentially added TBDMSCl (8.4 g, 55 mmol) and imidazole (4.01 g, 60 mmol). The mixture was stirred at rt overnight. Water was added and the two phases separated. The aq. phase was extracted with ether and the combined org. layers were dried over MgSO4 and concentrated to give the title intermediate as a colourless liquid (11.2 g, 100% yield).
후처리
- customthe two phases separated
- extractionThe aq. phase was extracted with ether
- dry with materiallayers were dried over MgSO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-275f0dbd67ea4aeaab698bfe230a815f
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08114867B2
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