Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-Amino-3-fluorophenol | HCID 2735919 | — |
| 반응물 | 4-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 11389493 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline | HCID 17979351 | — |
반응 단계
100 mg (660 μmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine (from example XVIII), 166 mg (1.31 mmol) of 2-fluoro-4-hydroxyaniline and 73.5 mg (1.31 mmol) of powdered potassium hydroxide are heated at 260° C. for 8 hours. For work-up, the mixture is cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated using a rotary evaporator. The residue is purified by preparative HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-b6ddfe09432349159627580791e74162 |
| 출처 메모 | uspto-grants-2010_06 |