Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran → 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran | HCID 17979342 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 생성물 | 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine | HCID 17979304 | — |
반응 단계
Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e3cf80b818b84914a527d46ea5c07013 |
| 출처 메모 | uspto-grants-2010_06 |