Trifluoroacetic acid → (4-Aminonaphthalen-1-yloxy)-acetonitrile

HRID 1641289노트

반응식

HRID 1641289 반응식
C(OC(=O)[NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][C:20]#[N:21])=[CH:10][CH:9]=1)(C)(C)C.FC(F)(F)C(O)=O.C(OCC)(=O)C>ClCCl>[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][C:20]#[N:21])=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 59553417(4-Cyanomethoxynaphthalen-1-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 59553077(4-Aminonaphthalen-1-yloxy)-acetonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of (4-cyanomethoxynaphthalen-1-yl)-carbamic acid tert-butyl ester (1.13 g, 3.8 mmol) in anhydrous dichloromethane (15 ml) at room temperature is added trifluoroacetic acid (5 ml). After 4 hours the mixture is poured into ethyl acetate (100 ml) and washed with saturated sodium bicarbonate solution (150 ml). The organic layer is then dried over anhydrous sodium sulfate and evaporated to dryness to give (4-aminonaphthalen-1-yloxy)-acetonitrile as a red brown solid.

후처리

  1. washwashed with saturated sodium bicarbonate solution (150 ml)
  2. dry with materialThe organic layer is then dried over anhydrous sodium sulfate
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-57af0d104b0849d989e0c18f38e76dab
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114873B2

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