홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

p-Toluenesulfonic acid → N-{5-[2-(4-bromophenyl)ethyl]-2,2-dimethyl-1,3-dioxan-5-yl}acetamide

HRID 1641527
노트
인쇄 미리보기

반응식

HRID 1641527 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([NH:15][C:16](=[O:18])[CH3:17])([CH2:13][OH:14])[CH2:11][OH:12])=[CH:4][CH:3]=1.CO[C:21](OC)([CH3:23])[CH3:22].C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2([NH:15][C:16](=[O:18])[CH3:17])[CH2:11][O:12][C:21]([CH3:23])([CH3:22])[O:14][CH2:13]2)=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 64952,2-DimethoxypropaneHCID 57624600N-[3-(4-bromophenyl)-1,1-bis(hydroxymethyl)propyl]acetamide

생성물 1

HCID 46202882N-{5-[2-(4-bromophenyl)ethyl]-2,2-dimethyl-1,3-dioxan-5-yl}acetamide수율 87.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of N-[3-(4-bromophenyl)-1,1-bis(hydroxymethyl)propyl]acetamide (42.2 g) of Reference Example 4, acetone dimethyl acetal (41.9 g) and a catalytic amount of p-toluenesulfonic acid in acetone (200 mL) was stirred at room temperature for one day. The reaction mixture was concentrated under reduced pressure, and the residual crude crystals were suspended in aqueous sodium hydrogen carbonate solution and collected by filtration to give the title compound (41.5 g) as white crystals.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-e73c4946036b4ed8a8cde575bbf2c225
출처 데이터셋
uspto-grants-2012_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08114902B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트