Sulfuric Acid → Methyl beta-D-ribofuranoside
반응식
[O:1]=[CH:2][C@@H:3]([C@@H:5]([C@@H:7]([CH2:9][OH:10])[OH:8])[OH:6])[OH:4].S(=O)(=O)(O)O.[C:16](=O)([O-])[O-].[Na+].[Na+]>CO>[O:1]([CH3:16])[C@@H:2]1[O:8][C@H:7]([CH2:9][OH:10])[C@@H:5]([OH:6])[C@H:3]1[OH:4]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
5 g of D-Ribose was dissolved in 100 mL of methanol and cooled to 0° C. 0.5 mL of concentrated sulfuric acid was added and the solution was stored at −20° C. for 48 hrs. Solution was neutralized by passage through a bed of sodium carbonate and evaporated under vacuum to a viscous oil. Crude material was purified on a silica column eluting with 10% methanol in ethyl acetate to yield 2.1 grams of methyl β-D-ribofuranoside.
후처리
- customevaporated under vacuum to a viscous oil
- customCrude material was purified on a silica column
- washeluting with 10% methanol in ethyl acetate
출처 및 근거
- ORD 기록
- ord-e17f9e9b96af4cb7b9fdfdc590781046
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08115026B2
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