4,4'-(2-Aminoethylidene)bisphenol → (1R,2S,3R,5S)-3-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-2-chloro-purin-9-yl}-5-(5-ethyl-tetrazol-2-yl)-cyclopentane-1,2-diol

HRID 1641892

반응식

HRID 1641892 반응식
C(OC(=O)O[C@H]1C[C@@H](N2C=NC3C2=NC(Cl)=NC=3Cl)C=C1)C.[Cl:23][C:24]1[N:32]=[C:31]2[C:27]([N:28]=[CH:29][N:30]2[C@@H:33]2[CH2:37][C@H:36]([N:38]3[N:42]=[N:41][C:40]([CH2:43][CH3:44])=[N:39]3)[C@@H:35]([OH:45])[C@H:34]2[OH:46])=[C:26](NCC(C2C=CC=CC=2)C2C=CC=CC=2)[N:25]=1.[NH2:62][CH2:63][CH:64]([C:72]1[CH:77]=[CH:76][C:75]([OH:78])=[CH:74][CH:73]=1)[C:65]1[CH:70]=[CH:69][C:68]([OH:71])=[CH:67][CH:66]=1>>[OH:78][C:75]1[CH:76]=[CH:77][C:72]([CH:64]([C:65]2[CH:66]=[CH:67][C:68]([OH:71])=[CH:69][CH:70]=2)[CH2:63][NH:62][C:26]2[N:25]=[C:24]([Cl:23])[N:32]=[C:31]3[C:27]=2[N:28]=[CH:29][N:30]3[C@@H:33]2[CH2:37][C@H:36]([N:38]3[N:42]=[N:41][C:40]([CH2:43][CH3:44])=[N:39]3)[C@@H:35]([OH:45])[C@H:34]2[OH:46])=[CH:73][CH:74]=1

참가 물질

4

반응물 3

HCID 217102804,4'-(2-Aminoethylidene)bisphenolHCID 58025019Carbonic acid (1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl ester ethyl esterHCID 86622803(1R,2S,3R,5S)-3-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(5-ethyl-tetrazol-2-yl)-cyclopentane-1,2-diol

생성물 1

HCID 86622807(1R,2S,3R,5S)-3-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-2-chloro-purin-9-yl}-5-(5-ethyl-tetrazol-2-yl)-cyclopentane-1,2-diol

실험 절차

This compound is prepared from carbonic acid (1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl ester ethyl ester (Intermediate AC) using a procedure analogous to that of (1R,2S,3R,5S)-3-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(5-ethyl-tetrazol-2-yl)-cyclopentane-1,2-diol (Intermediate BA6) by replacing 2,2-diphenylethylamine with 4,4′-(2-aminoethylidene)bis-phenol (second step b). MS (ES+) m/e 578.34 (MH+)

출처 및 근거

ORD 기록
ord-4f06d5aa2c794023acd59870f509dc38
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114877B2

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