(3'R)-1'-(Phenylmethyl)-1,3'-bipyrrolidine → (3R)-3-(Pyrrolidin-1-YL)pyrrolidine

HRID 1641899노트

반응식

HRID 1641899 반응식
C([N:8]1[CH2:12][CH2:11][C@@H:10]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:13]1([C@@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH2:17][CH2:16][CH2:15][CH2:14]1

참가 물질

4

반응물 1

HCID 66629680(3'R)-1'-(Phenylmethyl)-1,3'-bipyrrolidine

생성물 1

HCID 7176272(3R)-3-(Pyrrolidin-1-YL)pyrrolidine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A solution of (R)-1′-benzyl-[1,3′]bipyrrolidinyl (0.517 g, 2.24 mmol) in methanol (25 ml) under an atmosphere of argon is treated with palladium hydroxide on carbon (0.1 g). The reaction mixture is placed under an atmosphere of hydrogen, stirred at room temperature overnight and then filtered through Celite™ filter material. The filtrate is concentrated in vacuo to yield the title compound as a dark orange oil.

후처리

  1. filtrationfiltered through Celite™
  2. filtrationfilter material
  3. concentrationThe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-6a9e0c8e1b69458293c4bc6d6043da63
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114877B2

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