Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-(4-Amino-2-chlorophenoxy)-6-fluorobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,6-Difluorobenzonitrile | HCID 74695 | — |
| 반응물 | 4-Amino-2-chlorophenol | HCID 77578 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(4-Amino-2-chlorophenoxy)-6-fluorobenzonitrile | HCID 17979302 | — |
반응 단계
1.00 g (7.19 mmol) of 2,6-difluorobenzonitrile is initially charged in 10 ml of acetonitrile. 1.99 g (14.4 mmol) of potassium carbonate and 1.03 g (7.19 mmol) of 3-chloro-4-hydroxyaniline are added, and the mixture is heated at reflux for 45 min. The mixture is filtered and the filtercake is washed with ethyl acetate and DCM. The solvent is removed under reduced pressure and the residue is by column chromatography (silica gel 60, gradient column: mobile phase: DCM:petroleum ether=2:1, then DCM).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-63c7feb226134404a5bf0269df3955a5 |
| 출처 메모 | uspto-grants-2010_06 |