O-Phenylenediamine → Methyl (3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetate

HRID 1642141노트

반응식

HRID 1642141 반응식
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[C:9](OCC)(=[O:17])/[CH:10]=[CH:11]\[C:12]([O:14][CH2:15]C)=[O:13]>C(O)CC>[O:17]=[C:9]1[NH:8][C:1]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[NH:7][CH:10]1[CH2:11][C:12]([O:14][CH3:15])=[O:13]

참가 물질

4

반응물 2

HCID 7243O-PhenylenediamineHCID 5271566Diethyl Maleate

생성물 1

HCID 21027845Methyl (3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetate

시약·촉매·용매 1

HCID 10311-Propanol용매

실험 절차

Orthophenylenediamine (10 g, 92.4 mmol) and diethyl maleate (45 g, 646.8 mmol) were refluxed for 75 h in propanol. The solvent was removed using a rotary evaporator and the residue was purified by column chromatography (ethyl acetate/hexane 1:1).

후처리

  1. customThe solvent was removed
  2. customa rotary evaporator
  3. customthe residue was purified by column chromatography (ethyl acetate/hexane 1:1)

출처 및 근거

ORD 기록
ord-0f075b1158374d678740c17b3e90ed28
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119633B2

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