Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 4-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,4-Difluorobenzonitrile | HCID 77545 | — |
| 반응물 | 4-Amino-2-chlorophenol | HCID 77578 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile | HCID 17979347 | — |
반응 단계
2.00 g (14.4 mmol) of 2,4-difluorobenzonitrile, 2.06 g (14.4 mmol) of 3-chloro-4-hydroxyaniline and 3.97 g (28.8 mmol) of potassium carbonate in 20 ml of acetonitrile are heated at RF for one hour. Ethyl acetate is added, the mixture is filtered and the solvent is removed under reduced pressure. The residue is purified by column chromatography (silica gel 60), giving the product which is a regioisomer mixture with a ratio of 62:38.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-469b7561ac284cd882eeac1cf9b3c0ae |
| 출처 메모 | uspto-grants-2010_06 |