HCID 66756606, 화합물 → HCID 66757012, 화합물
반응식
[CH2:1]([O:3][C:4](=[O:30])[CH:5]([C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[C:15]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:14]=1)C(OC(C)(C)C)=O)[CH3:2]>C(O)=O>[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[C:15]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:14]=1)[CH3:2]참가 물질
3
실험 절차
2-(3-Benzyloxy-4-nitrophenyl)-malonic acid tert-butyl ester ethyl ester (5.00 g, 12.0 mmol) is suspended in formic acid (60 mL) and stirred at RT for 18 h. The solvent is removed under reduced pressure and the residue taken up in EtOAc (100 mL). The organic solution is extracted with saturated NaHCO3 (2×50 mL) and brine (30 mL), before being dried over Na2SO4 and concentrated to an oil. Purification by flash column (10-15% EtOAc/hexanes) affords (3-benzyloxy-4-nitrophenyl)-acetic acid ethyl ester as a yellow oil: MS (M+H)+=316.
후처리
- customThe solvent is removed under reduced pressure
- extractionThe organic solution is extracted with saturated NaHCO3 (2×50 mL) and brine (30 mL)