Methyl 5-bromopyridine-3-carboxylate → Methyl 5-[4-methyl-3-(trifluoromethyl)phenyl]pyridine-3-carboxylate

HRID 1642842노트

반응식

HRID 1642842 반응식
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[CH3:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][C:14]=1[C:22]([F:25])([F:24])[F:23]>>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=[N:4][CH:3]=2)=[CH:15][C:14]=1[C:22]([F:23])([F:24])[F:25]

참가 물질

3

반응물 2

HCID 699336Methyl 5-bromopyridine-3-carboxylateHCID 45158669[4-Methyl-3-(trifluoromethyl)phenyl]boronic acid

생성물 1

HCID 58002360Methyl 5-[4-methyl-3-(trifluoromethyl)phenyl]pyridine-3-carboxylate

실험 절차

2.2 g (10.3 mmol) of methyl 5-bromonicotinate and 2.5 g (12.4 mmol) of [4-methyl-3-(trifluoromethyl)phenyl]boronic acid were reacted according to the General Method 1A. Yield: 2.6 g (86% of theory)

출처 및 근거

ORD 기록
ord-0bbb90cdfa204df7936793569e0f9917
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119663B2

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