Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N'-Hydroxybenzenecarboximidamide → 4-({3-(3-Phenyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}carbonyl)-morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N'-Hydroxybenzenecarboximidamide | HCID 69186 | — |
| 반응물 | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002500 | — |
| 생성물 | 4-({3-(3-Phenyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}carbonyl)-morpholine | HCID 58002399 | — |
반응 단계
80 mg (0.20 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 44A) and 30 mg (0.22 mmol, 1.1 eq.) of N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 10 mg (10% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08119663B2 |
| 출처 데이터셋 | uspto-grants-2012_02 |
| ORD ID | ord-da5a26a8efa947c594c16a9e1cf01b11 |
| 출처 메모 | uspto-grants-2012_02 |