N-Hydroxybutyramidine → 1-(Cyclopentylcarbonyl)-3-(4-ethylphenyl)-5-(3-propyl-1,2,4-oxadiazol-5-yl)piperidine
반응식
[CH:1]1([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:22]([OH:24])=O)[CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.O[N:26]=[C:27]([NH2:31])[CH2:28][CH2:29][CH3:30]>>[CH:1]1([C:6]([N:8]2[CH2:9][CH:10]([C:22]3[O:24][N:31]=[C:27]([CH2:28][CH2:29][CH3:30])[N:26]=3)[CH2:11][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:13]2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1참가 물질
3
실험 절차
66 mg (0.20 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 7A) and 22 mg (0.22 mmol, 1.1 eq.) of N′-hydroxybutanimidamide were reacted according to the General Method 1. Yield: 12 mg (15% of theory)
출처 및 근거
- ORD 기록
- ord-f4e66cb8588d4387bcaaed8563ad46c7
- 출처 데이터셋
- uspto-grants-2012_02