3-fluoro-N'-hydroxybenzene-1-carboximidamide → {3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

HRID 1642999노트

반응식

HRID 1642999 반응식
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)[CH2:12][CH:11]([C:25](O)=[O:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:28][C:29]1[CH:30]=[C:31]([C:35](=[N:37]O)[NH2:36])[CH:32]=[CH:33][CH:34]=1>>[F:28][C:29]1[CH:30]=[C:31]([C:35]2[N:37]=[C:25]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:22])[F:24])[CH:16]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:8])[CH2:10]3)[O:26][N:36]=2)[CH:32]=[CH:33][CH:34]=1

참가 물질

3

반응물 2

HCID 40909723-fluoro-N'-hydroxybenzene-1-carboximidamideHCID 580021491-(Morpholin-4-ylcarbonyl)-5-[3-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

생성물 1

HCID 58002328{3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

실험 절차

100 mg (0.26 mmol) of the compound from Example 147A and 60 mg (0.39 mmol) of the compound from Example 73A were reacted according to the General Method 2. Yield: 75 mg (57% of theory)

출처 및 근거

ORD 기록
ord-6a93d1b339604641b9b6b6c67658667b
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119663B2

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