1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → 1-({3-[3-(1-Cyclopropylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}carbonyl)piperidine-4-carbonitrile

HRID 1643010노트

반응식

HRID 1643010 반응식
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:27](O)=[O:28])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].[CH:30]1([N:33]2[CH2:38][CH2:37][CH:36]([C:39](=[N:41]O)[NH2:40])[CH2:35][CH2:34]2)[CH2:32][CH2:31]1>>[CH:30]1([N:33]2[CH2:38][CH2:37][CH:36]([C:39]3[N:41]=[C:27]([CH:13]4[CH2:14][CH:15]([C:17]5[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=5)[CH2:16][N:11]([C:9]([N:6]5[CH2:7][CH2:8][CH:3]([C:1]#[N:2])[CH2:4][CH2:5]5)=[O:10])[CH2:12]4)[O:28][N:40]=3)[CH2:35][CH2:34]2)[CH2:31][CH2:32]1

참가 물질

3

반응물 2

HCID 580023321-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acidHCID 723495471-cyclopropyl-N-hydroxypiperidine-4-carboxamidine

생성물 1

HCID 580024541-({3-[3-(1-Cyclopropylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}carbonyl)piperidine-4-carbonitrile

실험 절차

155 mg (0.363 mmol) of the compound from Example 100A and 100 mg (0.545 mmol) of the compound from Example 75A were reacted according to the General Method 2. Yield: 76 mg (38% of theory)

출처 및 근거

ORD 기록
ord-c2510fbb9a594f95b8642085ff2aae7a
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119663B2

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