1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → (4-Hydroxypiperidin-1-yl) {3-{3-[2-(propan-2-yloxy)ethyl]-1,2,4-oxadiazol-5-yl}-5-[4-(trifluoro-methyl)phenyl]piperidin-1-yl}methanone
반응식
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:26]([OH:28])=O)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:30]=[C:31]([NH2:38])[CH2:32][CH2:33][O:34][CH:35]([CH3:37])[CH3:36]>>[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:20][CH:21]=3)[CH2:13][CH:12]([C:26]3[O:28][N:38]=[C:31]([CH2:32][CH2:33][O:34][CH:35]([CH3:37])[CH3:36])[N:30]=3)[CH2:11]2)=[O:9])[CH2:6][CH2:7]1참가 물질
3
반응물 2
생성물 1
실험 절차
100 mg (0.25 mmol) of the compound from Example 99A and 61 mg (0.38 mmol) of the compound from Example 65A were reacted according to the General Method 2. Yield: 82 mg (61% of theory)
출처 및 근거
- ORD 기록
- ord-afa2d67279614ca488b57aa097018147