N'-hydroxycyclobutanecarboximidamide → HCID 58002712, 화합물

반응식

[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25](O)=[O:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:29]=[C:30]([CH:32]1[CH2:35][CH2:34][CH2:33]1)[NH2:31]>>[CH:32]1([C:30]2[N:31]=[C:25]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:2][CH2:3][O:4][CH2:5][CH2:6]4)=[O:8])[CH2:10]3)[O:26][N:29]=2)[CH2:35][CH2:34][CH2:33]1

참가 물질

반응물 2

HCID 3413554N'-hydroxycyclobutanecarboximidamide

HCID 580024471-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

생성물 1

HCID 58002712HCID 58002712, 화합물

실험 절차

150 mg (0.388 mmol) of the compound from Example 81A and 88 mg (0.776 mmol) of N′-hydroxycyclobutanecarboximidamide were reacted according to the General Method 2. Yield: 124 mg (65% of theory)

출처 및 근거

ORD 기록: ord-c54d4a8745164ee1bc90b7e645f4336d
출처 데이터셋: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08119663B2

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