Sodium Iodide → 1-Chloro-2-(iodomethyl)benzene
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8]Br.[Na+].[I-:11]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][I:11]참가 물질
4
실험 절차
A mixture of 2-chlorophenylmethylbromide (4 g, 19.47 mmol) and NaI (14 g, 97.33 mmol) in acetone (40 ml) was stirred under reflux for 1 hour. The reaction mixture was cooled, filtered and concentrated in vacuo. The residue was triturated with hexane and filtered. The solution was concentrated in vacuo, and the resulting oil purified by flash chromatography (silica, hexane) to afford the title compound (4.67 g, 63%) as an oil: 1H NMR (CDCl3) δ 7.34 (4H, m), 4.54 (2H, s).
후처리
- temperatureunder reflux for 1 hour
- temperatureThe reaction mixture was cooled
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe residue was triturated with hexane
- filtrationfiltered
- concentrationThe solution was concentrated in vacuo
- customthe resulting oil purified by flash chromatography (silica, hexane)
출처 및 근거
- ORD 기록
- ord-54a2b6771e514d84afe5008bb341d1f5
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08119631B2
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