Benzaldehyde → 3-Amino-1-benzyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile

반응식

C(OC(=O)[NH:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]#[N:19])[CH:15]=2)[NH:10][CH2:9]1)(C)(C)C.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[NH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]#[N:19])[CH:15]=2)[N:10]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:9]1

참가 물질

반응물 2

HCID 240Benzaldehyde

HCID 66692977tert-Butyl (6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)carbamate

생성물 1

HCID 667576433-Amino-1-benzyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile

실험 절차

157A was prepared from 1C and benzaldehyde by procedures analogous to those described in Example 22A, followed by removal of N-Boc protecting group according to the procedures described in Example 22B.

후처리

customfollowed by removal of N-Boc protecting group

출처 및 근거

ORD 기록: ord-b87c47be8a964d36a4d4c5163738a1fd
출처 데이터셋: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08119808B2

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