Sulfuryl chloride → Ethyl 6-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate

HRID 1643920노트

반응식

HRID 1643920 반응식
[O:1]=[C:2]1[N:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[NH:3]1.S(Cl)([Cl:19])(=O)=O>C(O)(=O)C>[Cl:19][C:13]1[CH:14]=[CH:15][C:4]2[NH:3][C:2](=[O:1])[N:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:5]=2[CH:12]=1

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 303857Ethyl 2-oxo-2,3-dihydro-1H-benzo[D]imidazole-1-carboxylate

생성물 1

HCID 10354291Ethyl 6-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
90 °C

실험 절차

A mixture of 7.00 g (33.9 mmol) of ethyl 2-oxo-2,3-dihydrobenzimidazole-1-carboxylate (IV) and 3.02 ml (37.3 mmol) of sulfuryl chloride in acetic acid (90 ml) was stirred at 90° C. for 1 h. The cooled reaction mixture was poured into ice-water. The precipitated solid was filtered off, washed with water, dried in vacuo and recrystallized from ethyl acetate.

후처리

  1. customThe cooled reaction mixture
  2. filtrationThe precipitated solid was filtered off
  3. washwashed with water
  4. customdried in vacuo
  5. customrecrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-ab703d4154b44b05a2319041a0d3e6c1
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119676B2

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