4-Heptanamine → N-(heptan-4-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

반응식

[CH3:1][N:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][C:4]([CH3:10])=[N:3]1.[CH3:11][CH2:12][CH2:13][CH:14]([NH2:18])[CH2:15][CH2:16][CH3:17]>>[CH3:11][CH2:12][CH2:13][CH:14]([NH:18][C:7]([C:6]1[N:2]([CH3:1])[N:3]=[C:4]([CH3:10])[CH:5]=1)=[O:9])[CH2:15][CH2:16][CH3:17]

참가 물질

반응물 2

HCID 386654-Heptanamine

HCID 5877211,3-Dimethyl-1H-pyrazole-5-carboxylic acid

생성물 1

HCID 57527752N-(heptan-4-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

실험 절차

Prepared in a similar manner to example 4 using 1,3-dimethyl-1H-pyrazole-5-carboxylic acid and 4-heptylamine. 1H NMR (500 MHz, CDCl3): δ 0.90 (t, 6H, J=7.2 Hz), 1.41 (m, 4H), 1.50 (m, 4H), 2.27 (s, 3H), 3.77 (s, 3H), 4.09 (m, 1H), 6.49 (d, 1H), 6.53 (s, 1H). MS (M+H, 238).

출처 및 근거

ORD 기록: ord-13b56ac259e04c34bb11b7d7ff25535b
출처 데이터셋: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08124121B2

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