1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → Methyl 4-[2-(4-aminopiperidin-1-yl)ethyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

HRID 1644364노트

반응식

HRID 1644364 반응식
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]2[C:22]3[CH:23]=[C:24]([C:27]([O:29][CH3:30])=[O:28])[CH:25]=[CH:26][C:21]=3[O:20][CH2:19][C:18]2=[O:31])[CH2:11][CH2:10]1)=O)(C)(C)C.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]2[C:22]3[CH:23]=[C:24]([C:27]([O:29][CH3:30])=[O:28])[CH:25]=[CH:26][C:21]=3[O:20][CH2:19][C:18]2=[O:31])[CH2:11][CH2:10]1

참가 물질

3

반응물 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 66774852Methyl 4-(2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate2회

생성물 1

HCID 66774773Methyl 4-[2-(4-aminopiperidin-1-yl)ethyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

실험 절차

Methyl 4-(2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate (Intermediate 85) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was used without further purification for the next step (quantitative yield).

후처리

  1. customThe crude trifluoro acetate of the title compound was used without further purification for the next step (quantitative yield)

출처 및 근거

ORD 기록
ord-fb9a59f11077416aa2c81511477f28c1
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124602B2

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