Ethyl oxoacetate → 6,7-Difluoro-1,2-dihydroquinoxalin-2-one

HRID 1644442노트

반응식

HRID 1644442 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[F:8].[O:11]=[CH:12][C:13](OCC)=O>C(O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[F:8])[NH:9][C:12](=[O:11])[CH:13]=[N:10]2

참가 물질

4

반응물 2

HCID 70211Ethyl oxoacetateHCID 27367551,2-Diamino-4,5-difluorobenzene

생성물 1

HCID 63243396,7-Difluoro-1,2-dihydroquinoxalin-2-one수율 73%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 4,5-difluorobenzene-1,2-diamine (4.7 g, 32.6 mmol) in ethanol (75 mL) was added ethyl oxoacetate (50 wt % in toluene, 13.3 mL, 65.3 mmol). The reaction was stirred at room temperature overnight. The resulting precipitate was collected by filtration, washed with ethanol, and dried under reduced pressure to give 4.3 g (73%) of the product as a colorless solid.

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethanol
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-172bb4d2f4e143a48ceaafc790a78f86
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124602B2

반응 노트

불러오는 중…